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The urine proteome represents a rich source of physiological information. Profiling of these thousands of proteins and peptides (polypeptides) using high resolution capillary electrophoresis coupled mass spectrometry (CE-MS) allows better understanding and in depth diagnosis of most known diseases. We have established a proteomic database of human urinary polypeptides. This library can be used as a rich source of biomarkers for a wide range of diseases. More than 3,300 urine samples were analysed CE-MS, yielding an average of 1,500 polypeptides per sample. All these CE-MS data were processed to identify and quantify individual peptides. The resulting database currently contains 4,954 different urinary peptides that can be used to build robust classifier models for diagnosis, stratification, and monitoring of a wide range of diseases, such as prostate and bladder cancer as well as kidney and vascular diseases.

The human urinary proteome database is accessible via "DataExchange".